During an interview with Jon Kutner, Fun Lovin' Criminals frontman Huey Morgan said that he wanted to create a track that sounded like a song Mexican-American guitarist Carlos Santana would compose.

He felt connected to him because of their Latino heritage, and he explained that he did not want to copy Santana's style exactly, but rather to put some of his "flavor" into the song.

He listened to the 1970 Santana album Abraxas for ideas, and he settled on sampling "Happy Anniversary" by Australian rock music group Little River Band for "Loco".

Morgan achieved the guitar's sound by playing a 1959 Les Paul Junior with a Tech 21 device going through a Fender Pro amplifier.

[4][5] The song and band appeared in a television advertisement for Miller beer shortly before its release,[6] and this exposure allowed the song to become Fun Lovin' Criminals' highest-charting single in the United Kingdom when it debuted and peaked at number five on the UK Singles Chart on February 11.