The neighborhood is also noted as being the home of Fort McHenry and the western end of its namesake tunnel that carries eight lanes of Interstate 95 under the river.

When Fort McHenry blocked the attempted invasion of Baltimore's inner harbor by British warships in September 1814, it was located on a grassy peninsula that was used for pasture.

On June 10, 2013, a tornado hit the Locust Point area as a part of a severe storm system sprawling across the East Coast.

[9] Procter & Gamble chose the Locust Point neighborhood as the location its second East Coast soap manufacturing plant in the late 1920s, reflecting the strengths of Baltimore's industrial infrastructure in the early 20th century.

In 1993, Procter & Gamble set aside reserves to fund a major restructuring of the corporation, including plant consolidation.

In 1996, A&E International, a Korean firm, purchased the property with the intent to manufacture a specialty liquor for shipping to the Far East.

Struever Brothers Eccles & Rouse rehabilitated the historic waterfront located at the end of Hull Street, calling it Tide Point.

Three silos next to the company's campus now display murals of Michael Phelps, Ray Lewis and Cal Ripken Jr.[10] There are two marine terminals of the Helen Delich Bentley Port of Baltimore located within the neighborhood, as well as the massive Domino sugar factory, a reminder that the industrial use of Baltimore Harbor is still a very important component of the local economy.