The name is derived from the word loď (i.e. 'boat', 'ship') and the old Czech adjective loděná (řeka), meaning "the river on which boats are ridden".

[2] The Loděnice originates in the territory of Řevničov in the Džbán range at an elevation of 497 m (1,631 ft) and flows to Srbsko, where it enters the Berounka River at an elevation of 210 m (690 ft).

[1] The river also briefly crosses the territory of the town of Beroun.

The river flows through the municipal territories of Řevničov, Třtice, Mšec, Mšecké Žehrovice, Stochov, Kačice, Tuchlovice, Kamenné Žehrovice, Doksy, Družec, Bratronice, Horní Bezděkov, Malé Kyšice, Chyňava, Unhošť, Svárov, Ptice, Nenačovice, Chrustenice, Loděnice, Svatý Jan pod Skalou, Beroun and Srbsko.

The lower course flows through the Bohemian Karst Protected Landscape Area.