Located on the northern side of the River Sutlej, it is bounded to the north by the districts of Multan, Khanewal and Vehari, to the south by Bahawalpur, to the east lie the districts of Vehari and Bahawalpur; while district Multan lies on the western side.

Lodhran was split off as a separate district from Multan in 1991.

[3] Lodhran District is spread over an area of 2,778 square kilometres and is subdivided into three tehsils (Lodhran, Kahror Pakka and Dunyapur) which contain a total of 73 Union Councils:[5] (km²)[7] (2023) (ppl/km²) (2023) (2023)[8] As of the 2023 census, Lodhran district has 323,866 households and a population of 1,928,299.

[15] The most widely spoken first language is Saraiki (70%), which is used by the major indigenous social groups of the Joya , Baloch, Awan, Arain, Kanju, Uttera/Uttero, Ghallu, Bhutta, Lodhra, Metla, Chaner Syed, Qureshi, Tareen and Pathan.

The percentage of the district's population who declared Urdu as their language at the 1998 census was 9%; this includes these Haryanvi speakers as well as other, smaller, groups of Muhajirs such as the Mughal.