She gained international popularity for her role as "Francesca" in the Argentine Disney Channel series Violetta.

[4] In 2009, she was cast as a performer for the "Il Mondo di Patty" tour, the Italian version of the widely successful Argentine children's program, Patito Feo.

[5] While living in Milan and attending M.A.S., she learned of a Disney Channel Latin America casting search for Italian actors, who also spoke Spanish.

One week after auditioning, she successfully obtained a role on Violetta, the network's latest tween musical television series.

[8] Comello returned to film the third and final season of "Violetta" which began production in Buenos Aires in March 2014 and ended in late November of that same year.

[9] In late August 2016, Comello was revealed as a cast member in the Italian comedy film Poveri ma ricchi ("Poor but rich" in English).

A special website was created to allow fans to vote on various international cities for possible concert locations in Latin America, Europe, Israel, and the United States.

[13] In 2014, Comello began writing songs for her second album during breaks on the set while filming of the final season of Violetta in Buenos Aires.

On 24 January 2015, Comello announced to fans via her official Twitter account that her second album, Mariposa ("Butterfly"), would be released on 3 February 2015 in Italy.

Comello skipped the 2015 world tour with the cast of Violetta to focus on promoting her material as a solo artist.

[19] Comello also released a Polish version of "Sin usar palabras" featuring Szymon Chodyniecki.

[21] On 13 May 2016, Comello released the Italian-language song "Non cadiamo mai" ("Never Fall" in English) as the lead single from her upcoming untitled third studio album.

The music video, filmed in Rome, was premiered as an exclusive for Corriere della Sera, the Milan-based newspaper.

Auditions[31] began in Milan in late 2015; the 7th season of Italia's Got Talent premiered on 16 March 2016[32] on Sky Uno, where it aired weeknights.

[33] Comello is the host of the new music themed game show, "Singing in the Car", which premiered on 5 September 2016 in Italy on the network, TV8.

The couple dated for four years and later married in a small civil ceremony at the city hall in San Daniele del Friuli, Italy on 1 April 2015.

[36][37][38] In November 2019, Comello announced to fans via Instagram that she and her husband were expecting their first child, a boy, in early spring.