It is served by Sydney Trains' T4 Eastern Suburbs & Illawarra Line services and limited NSW TrainLink South Coast Line services.

Loftus station opened on 9 March 1886 as Loftus Junction when the Illawarra line was extended from Sutherland to Waterfall.

It was rebuilt in 1979 as part of the extension of the electrification from Loftus Junction to Waterfall.

[3][4] From 1886 until 1991, Loftus was the former junction of the branch line to the Royal National Park which branched off immediately south of the station.

[5] U-Go Mobility operates two bus routes via Loftus station, under contract to Transport for NSW: