The 2nd constituency of Loire-Atlantique is a French legislative constituency in the Loire-Atlantique département, covering the eastern part of the city of Nantes.

Like the other 576 French constituencies, it elects one MP using the two-round system, with a run-off if no candidate receives over 50% of the vote in the first round.

From 1958 to 1986, the constituency was made up of the cantons of Nantes-5, 6 and 7.

[1] In 1986, this was changed to the cantons of Nantes-2, 3, 4 and 9.

(In 2015, Nantes-9 was abolished and its territory split between Nantes-2 and 7.)