Her marriage to Bill W. began to be challenging due to the combination of a series of ectopic pregnancies and his drinking problem.
Without children, she left Stepping Stones, the family home, gardens, archives and a writing studio (nicknamed "Wit's End" and "The Shack") on 8.5 acres in Bedford Hills, New York that she and Bill had owned since 1941, to the nonprofit, tax-exempt privately run Stepping Stones Foundation.
She served as Stepping Stones Foundation's first president from 1979 to 1988 and led its programs to increase education, awareness and prevention of alcoholism.
The film is based on the 2005 book of the same name written by William G. Borchert, author of the screen play for the 1989 film My Name Is Bill W., based on the story of Alcoholics Anonymous founder Bill Wilson, in which she was portrayed by JoBeth Williams.
She was also featured in a 2012 part documentary biographical film Bill W., directed by Dan Carracino and Kevin Hanlon.
[6] An excerpt from a letter written by Lois W. and sent to her husband was sampled in the song "Adamord" by American ambient/drone duo Stars of the Lid on the album Music for Nitrous Oxide.