[3] Lollapalooza Chile has featured a range of international artists such as The Killers, Jane's Addiction, Kanye West, Deftones, Fatboy Slim, Thirty Seconds to Mars, The Flaming Lips, Arctic Monkeys, Foo Fighters, Björk, MGMT, Tinie Tempah, Sublime with Rome, Foster the People, Calvin Harris and Armin Van Buuren.

[4][5] The 2013 lineup included The Black Keys, Pearl Jam, Queens of the Stone Age, Keane, Deadmau5, A Perfect Circle, Franz Ferdinand, The Hives, and many others.

The Chilean contingent of the 2013 lineup included Banda Conmoción, Gepe, De Saloon and Chancho en Piedra.

In mid-November 2010, the American musician Perry Farrell announced that the twentieth version of Lollapalooza festival would be held for the first time outside the United States; The site chosen was the Parque O'Higgins in Santiago, Chile, on 2 and 3 April 2011.

When the lineup was first revealed it was very poorly received by many festival fans, there were only a few big-name artists such as Björk, MGMT, Joan Jett and Foo Fighters, but by the time the festival finally started many popular artists such as Arctic Monkeys Calvin Harris, Skrillex, Tinie Tempah and Foster the People, among others were in the lineup.

The lineup was very well received by the people as it brought many quality, big-name artists such as Pearl Jam, Keane, Franz Ferdinand, Queens of the Stone Age, The Black Keys, The Hives, Kaiser Chiefs, deadmau5, Passion Pit, Two Door Cinema Club, Of Monsters and Men, A Perfect Circle, Hot Chip and Foals, and many others.

Jorge Gonzalez, ex leader of a Chilean 80's rock band known as Los Prisioneros cancelled his presentation after suffering a stroke on February 8, 2015.

The headliners of the 2019 lineup included Kendrick Lamar, Arctic Monkeys, Twenty One Pilots, Lenny Kravitz, Post Malone, Sam Smith and Tiesto.

The headliners of this lineup are: Olivia Rodrigo, Rüfüs Du Sol, Justin Timberlake, Alanis Morissette, Tool, and Shawn Mendes.

Other big artists that are performing there but are not headliners are: Benson Boone, Girl in Red, Tate McRae, and Teddy Swims[9]