[3] Lookboonmee began training Muay Thai at seven years old at her father Boonmee Suphisara's gym.

[10] Lookboonmee transitioned to mixed martial arts in 2017, training under coach George Hickman at Tiger Muay Thai.

[10] She made her amateur debut for Thailand Fighting Championship at the music/MMA festival event RockWars on September 23.

[11][12] She won the bout, submitting Filipina fighter Krisna Limbaga by rear naked choke in the second round,[13][14][12] after which she quickly turned pro, signing with Invicta Fighting Championships in October.

[21] Lookboonmee faced Jinh Yu Frey on October 4, 2020 at UFC on ESPN: Holm vs.

[23] As the first bout of her new multi-fight contract, Lookboonmee faced Sam Hughes on May 1, 2021 at UFC on ESPN: Reyes vs.

[32] As the first bout of her new multi-fight contract, Lookboonmee was scheduled to face Elise Reed on February 4, 2023, at UFC Fight Night 218.