[2] Edward Warren has been living in Thailand for nearly 6 years when he receives a frantic telephone call: His estranged family have been badly injured in a car accident in New Hampshire.

[4] Picoult researched the behavior of gray wolves with the help of Shaun Ellis, the founder and head of Wolf Pack Management at Combe Martin Wildlife Park.

[5] Lone Wolf is told through multiple character perspectives, including Luke, Cara, Georgie, Edward, and the final chapter is narrated by Barney.

Picoult has employed this writing technique in a number of her novels, including House Rules, My Sister's Keeper, Songs of the Humpback Whale, Change of Heart, Sing You Home, and Handle with Care.

[9][10] In comparison, Barbara King, a reviewer for the Washington Post, criticized the book as lacking the balance of Picoult's earlier work.