Chisenhall attended West Carteret High School in Morehead City, North Carolina, graduating in 2006.

[4] He played 68 games in 2008 for the Indians Class A Short Season Affiliate the Mahoning Valley Scrappers posting a .290 AVG with 5 HR and 45 RBI.

On June 27, 2011, Chisenhall was promoted from the Class AAA Columbus Clippers, and went 2-for-4 in his major league debut against the Arizona Diamondbacks.

[6] On July 6, 2011, Chisenhall hit his first major league home run off of Boone Logan of the New York Yankees.

[7] On July 7, 2011, Chisenhall was hit with a fastball thrown by Toronto Blue Jays pitcher Carlos Villanueva and had to leave the game with facial contusions.

On June 9, 2014, Chisenhall became the first player in MLB history to have 5 hits, 3 home runs, and 9 RBI in 5 plate appearances.

On June 10, after poor offensive output, Lonnie was again optioned to Cleveland's Class AAA Columbus Clippers.

Replay showed that the ball did not actually hit Chisenhall, but Yankees manager Joe Girardi decided not to challenge the call.