Directed by Tom Ropelewski from a script written by Tom Ropelewski and Leslie Dixon, the film included John Travolta and Kirstie Alley reprising their roles as James and Mollie Ubriacco, respectively, while David Gallagher and Tabitha Lupien portray Mikey and Julie, respectively.

[4][5] Where the previous films were done from the perspective of human babies, the script is flipped when two dogs Trooper and Precious are in a fling.

As a surprise one day James takes Mikey to the pound to pick out a dog for Christmas only to run into the puppy who is on his way to being destroyed after being there too long.

Meanwhile James is called to work on Christmas Eve to fly Samantha to a private estate in northern New York and she effectively strands him there with her.

George Segal, who portrayed Albert, the first film's antagonist and Mikey's biological father, reappears briefly in a dream sequence.

"[7] Metacritic, which uses a weighted average, assigned the film a score of 26 out of 100, based on 19 critics, indicating "generally unfavorable" reviews.

[11] Dan Cox of Variety wrote: "Stretching a premise that one might say has gone to the dogs, Look Who's Talking Now runs feebly on the calculated steam of its forebears".

[12] Rita Kempley of The Washington Post wrote: "Take the 'dle' out of 'poodle' and you've pretty much got the leitmotif of Look Who's Talking Now, a crude and mawkish film in which dogs attempt to communicate with Kirstie Alley and John Travolta".

[13] Stephen Holden of The New York Times was somewhat positive, writing that "the sound of stars mouthing the inner thoughts of dogs is somehow funnier than that of grownup actors doing wisecracking voice overs for gurgling infants".

[14] Peter Rainer of the Los Angeles Times was also somewhat positive, calling the film "borderline pleasant" because Travolta and Alley "are a marvelous team".