It contained educational text articles that covered a wide variety of topics from volcanoes to the Loch Ness Monster; a long running science fiction comic strip, The Trigan Empire; adaptations of famous works of literature into comic-strip form, such as Lorna Doone; and serialized works of fiction such as The First Men in the Moon.

The illustrators who worked on the magazine included Fortunino Matania, John Millar Watt, Peter Jackson, John Worsley, Ron Embleton, Gerry Embleton, C. L. Doughty, Wilf Hardy, Dan Escott, Angus McBride, Oliver Frey, James E. McConnell, Kenneth Lilly, R. B. Davis and Clive Uptton.

The first issue of Look and Learn was dated 20 January 1962, and contained a wide spectrum of features ranging from articles on history (Rome, the Houses of Parliament, the story of King Charles I, "The Dover Road", "From Then Till Now"), science ("Eyes on Outer Space"), geography and geology (The Grand Canyon, "The Quest for Oil"), art (Vincent van Gogh), nature ("The story of a seed", "Your Very Own Basset Hound"), literature (The Arabian Nights, and its editor Sir Richard Burton), and travel ("The Children of Tokio").

To advance this principle, the features were clearly and briskly written and illustrated by some of the finest artists of the era resulting in a magazine of unmatched quality.

This amalgamation was overseen by recently appointed editor John Davies who had replaced Sanders when the latter left to edit the short-lived Ranger in 1965.