Lopo Fernandes Pacheco (died 22 December 1349), was the first of his lineage to accede to the highest ranks of the nobility, that of a rico-homem, in the Kingdom of Portugal.

[12] Due to his constant presence in the curia regis, most of his estates, purchased or donated by the King, were situated along the Tagus in the Santarém District as well as in Lisbon and surrounding areas.

[13] Lopo Fernandes Pacheco died on 22 December 1349 and was buried in Lisbon Cathedral, also the final resting place of King Alfonso IV.

The most relevant events of his life and his marriage were engraved on a stone slab, commissioned by King Afonso IV, which was placed on the wall above his sarcophagus.

[15] They were the parents of: By 1345 he was already married to his second spouse, María Rodríguez de Villalobos,[18][7] who was still alive in 1367 and was the daughter of the Leonese noble Ruy Gil de Villalobos (died 1307) and of Teresa Sánchez, an illegitimate daughter of King Sancho IV of Castile,[19] whose first husband was João Afonso Telo, 1st Count of Barcelos.