[5][6] On March 16, the Republican leadership of the state House (Speaker Mike Chenault, Craig Johnson, and Charisse Millett) removed Reinbold from the majority caucus for her vote and stripped her of most of her committee assignments.

An Alaska Airlines policy, as well as a federal regulation, required passengers to wear masks except while eating or drinking.

In April 2021, Alaska Airlines banned Reinbold from its flights, citing "her continued refusal to comply with employee instruction regarding the current mask policy.

[11][12] In April 2023, Reinbold filed a lawsuit against Alaska Airlines and its employees citing a medical condition prevented her from following the mask requirement.

[14] Reinbold has frequently posted COVID-19 misinformation on Facebook, where she promotes the use of hydroxychloroquine and ivermectin and expresses vehement opposition to face-covering and vaccine mandates.

[15] She disagreed with Governor Mike Dunleavy, who wrote, "It is lamentable that the good citizens of Eagle River and Chugiak are deprived of meaningful representation by the actions of the person holding the office of Senator."

As Senate Judiciary Committee chair, she held hearings highlighting testimony from witnesses who questioned masks' usefulness and the consequences of government emergency orders.

[17][16] Despite the recommendations of Alaska health officials who have said that wearing masks and following measures like social distancing help slow the spread of COVID-19, Reinbold has accused Dunleavy's administration of being "wild" about what she termed "these experimental" COVID-19 vaccines and "bragging over 100,000 Alaskans have gotten them", and characterized the administration as seeking disaster declarations in order to get mass vaccination clinics.

The next day, Capitol security escorted her out of a House Health and Social Services Committee meeting because she refused to wear a mask.