"Lord Give Me a Sign" is a song by American hip hop recording artist DMX, released as the second single from his sixth studio album Year of the Dog... Again (2006).

Even though the album's cover has the RIAA Parental Advisory sticker, this song is entirely free of profanity.

DMX has since decided to return to rap after being encouraged by Mase to wait for God's calling to do so.

It is also rumored that DMX made this song because he needs a sign to preach or stay rapping.

The song is about how DMX struggles with "trials and tribulations" throughout his life, all the while seeking strength from God to win the battles he faces.