Lorena Cuéllar Cisneros (born 20 February 1962) is a Mexican politician affiliated with the National Regeneration Movement (MORENA) who serves as the Governor of Tlaxcala.

This bid did not prosper, and citing a conflict with Governor Mariano González Zarur that left her out in the cold within the party, Cuéllar left the PRI in January 2012 and ran as the Party of the Democratic Revolution (PRD) coalition candidate, winning election to the Senate of the Republic.

[1] Cuéllar took leave from the Senate in February 2016 in order to run as the PRD candidate for Governor of Tlaxcala; after a two-percentage-point loss to the PRI coalition candidate Marco Antonio Mena Rodríguez, she returned to the Senate.

In April 2017, she and two other legislators left the PRD and, alongside independents and members of the National Regeneration Movement (Morena), joined the PT caucus in a spat over commission seats, in which the party motioned to remove a senator who had recently left the PRD from the chamber's Administration Commission and replace her with new party president Alejandra Barrales; the defections swelled the PT's ranks from 7 to 16 senators.

She was also included on Morena's party list, in the third position from the fourth electoral region, assuring her of a seat either way.