In 1487 he wrote a letter of introduction to Pope Innocent VIII for his half brother Wilhelm who was being sent to the Vatican as emissary of Archbishop Hermann IV of Cologne.

An adherent of the German humanism movement of the late 15th and early 16th centuries and renaissance man, he sought to bring reforms to the Catholic Church from within.

Following the meeting in Würzburg, Lorenz wrote a letter of recommendation to Duke Frederick the Wise of Saxony stating: "Your beloved Excellency you should not allow this pious man, Dr. Martin Luther to leave your boundaries because something unjust might happen to him."

(Euere Liebden wolle ja den frommen Mann Doktor Martinus nicht wegziehen lassen, denn ihm geschähe Unrecht.

(Welche des Bischofen Wort diesem Churfürsten von Sachsen so wol gefielen, dass er mirs, Spalatino, mit eigener Hand umgeschrieben zur Lochau zuschickt, mich auch noch um diese Wort wenig Wochen vor ihrem Abschied von diesem Jammerthal durch Joachim Sack fragen liess .

Baier reports that the historians von Seckendorff, Lingke, Strobel, Walch, Engelhardt, Vierort, Tentzel, Löhe, Shornbaum and Köstlin (in contrast to Scharold) agreed with Splatin that had Lorenz lived longer, the Episcopate of Würzburg would have gone over to the Protestants.

Had this Bishop Lorenz von Bibra lived longer, the people around him would have thought that he would have accepted the holy Evangelium, since he had an even thinking of the Roman papal attitude and also the newly created gülden Gnadenjahr dealing with indulgences."

(Ich hab auch mal Edelleut aus Franken davon hören reden, dass sie sagten: Wenn ein Edelmann wär kommen und hätt ihn gebeten um Gunst, etlich Güter zu versetzen, wenn er gehört hat, dass er einen Sohn oder Tochter wollt damit ausstatten, in ein Kloster zu geben, so hätt er gesagt: "Lieber, gib deiner Tochter einen Mann, gibs nicht iu’s Kloster.

(Wenn der Bischof Lorenz von Würzburg einen bösen Buben sah, sagte er: ei, nur ins Kloster mit dir, du bist weder Gott noch den Menschen nutz)A chapel at Grimmenthal was erected by a Würzburg Captain which was dedicated by the Suffragan bishop of Lorenz, Georg von Bipolis, on August 24, 1498.

Bishop Lorenz is also used as an important character in the 2010 historical novel Die Königin der Gaukler (Queen of the Jugglers) by Guido Dieckmann.

It has been noted that Lorenz appointed a very large number of his Bibra relatives to government positions in the Bishopric of Würzburg and that his successor, Konrad II von Thungen, also followed this same pattern but to an even greater degree.