Loreto Secondary School, Kilkenny is a Roman Catholic voluntary secondary school for girls in Kilkenny, Ireland.

It was founded by the Sisters of Loreto in 1868 as a boarding and day school for girls.

Its first home was, for a brief time, in Patrick Street.

The sisters and school then moved to the building that now is home to the Good Shepherd Centre.

A new campus was completed on the Granges Road in 1980 when the school transferred to its present location.