In 1959 she was discovered by Silvio Gigli, which led her to take part in the radio competition, Dino Verde Disco Magico, presented by Corrado with an orchestra conducted by Gianni Ferrio.

[18] In 1962 she made her debut as a child actress in the RAI television prose Sotto processo with the direction of Anton Giulio Majano, broadcast on the Secondo programma.

Subsequently, Loretta was in the cast of many other famous Rai television dramas, in which she interpreted characters of fragile and needy girls (many times paired with another child actor, Roberto Chevalier, who later became a well-known voice actor) including Robinson non-deve morire (1963) by Vittorio Brignole, Demetrio Pianelli (1963) by Sandro Bolchi, I miserabili (1964), also by Bolchi in which she plays the role of Cosette as a child, Una tragedia americana (1962), Delitto e castigo (1963 ) and La cittadella (1964), all three directed by Anton Giulio Majano, Vita di Dante (1965) by Vittorio Cottafavi, in which she plays Beatrice, Questa sera parla Mark Twain and Scaramouche, with Domenico Modugno, both broadcast in 1965 and directed by Daniele D'Anza and in an episode of Le indagini del Commissario Maigret, directed by Mario Landi (1966).

In these dramas Loretta has the opportunity to support great Italian actors such as Lilla Brignone, Gino Cervi, Andreina Pagnani, Paolo Stoppa, Rina Morelli, Giorgio Albertazzi and many others.

In 1964, under the direction of Beppe Recchia, she was also in the cast of the children's drama C'era una volta la fiaba with Arturo Testa and Santo Versace; of the same year is also Le avventure della squadra di stoppa directed by Alda Grimaldi, another television drama aimed at children[19] Starting in 1965, having already participated in many television productions, she also dedicated himself to dubbing: she is the Italian voice of Tweety in the Warner Bros. Merrie Melodies (flanked by Gigi Proietti, who dubbed Sylvester the Cat), and famous actresses such as Katharine Ross, Kim Darby, Mita Medici, Agostina Belli, Ornella Muti and Silvia Dionisio; in the same period she deepend her studies in diction, piano and singing.

In 1968 she ventured for the first time with an adult role, taking part as the female protagonist of the play La freccia nera also directed by Anton Giulio Majano and based on the novel of the same name by Robert Louis Stevenson, in which she is flanked by Aldo Reggiani, Arnoldo Foà and Adalberto Maria Merli; the drama was successful (with peaks of 20 million viewers), and Loretta reached great fame.

In the summer of the same year Loretta led the show Estate insieme with Renzo Arbore, promoting emerging bands and solo singers, performing with her sister Daniela in the Boomerang Dance.

She was then alongside Pippo Baudo in the radio program Caccia alla voce, in which she replaced the actor Franco Rosi because he is sick, beginning to perform as an imitator, surprisingly enjoying great success, so much so that the conductor wants her with him in the television variety La freccia d'oro.

In the autumn of the same year she returned to Italy and, together with the imitator Alighiero Noschese, was in the Saturday night variety Formula due, in which the couple performed a series of imitations and parodies and in which Loretta sang the theme song initial Molla tutto and promoted her second album, entitled Formula 2; this variety was the most popular Italian television program of 1973, with an average of 26 million viewers and it was also one of the first color TV shows experimentally recorded by Rai.

In 1978, the Goggi sisters together with Pippo Franco, Oreste Lionello and the whole Bagaglino company, directed by Antonello Falqui, made the television variety Il ribaltone broadcast on Rai's Network 1, in which they sing the final theme Voglia.

In the autumn of the same year, Loretta returned to work as a soloist on television, conducting on Rai 1 the first edition of the Saturday night variety Fantastico, combined with the Italian Lottery, together with Beppe Grillo and the then newcomer Heather Parisi, directed by Enzo Trapani.

In 1980 Loretta published the summer single Notti d'agosto, written for her by her dear friend Franco Califano and embarked on a new international tour with her sister Daniela entitled Supergoggi which goes up to the countries of Latin America.

Cursed spring sold over two million copies (of which many covers will be recorded in various foreign languages), receiving the gold disc and the platinum disc, soon becoming an evergreen of Italian music[25][26] The album containing Maledetta primavera, entitled Il mio prossimo amore, was released in the autumn of the same year, on the occasion of the TV show Hello Goggi, an early evening variety totally focused on Loretta and her imitations, which marks her passage from Rai to the then newborn Canale 5 (of which Hello Goggi was absolutely the first variety show).

In the spring of 1983 Loretta went from Canale 5 to Rete 4 (a television station owned by the Arnoldo Mondadori Editore group at the time), where she conducted, together with Paolo Panelli and Luciano Salce, Gran varietà, a show on the early evening of Sunday.

In 1984 she recorded the song Un amore grande, written by Umberto Tozzi and Giancarlo Bigazzi and programmed to go to the competition at the Sanremo Festival, but Loretta gave up at the last moment her participation communicating that with an ANSA press release.

She returned to Sanremo in 1986, this time however as host of the 36th edition of the Festival: Goggi is the first woman to lead the event as the main presenter, achieving great success in terms of audience.

In the mid-eighties there was a decisive turning point in the choice of Loretta's repertoire: in fact, she abandoned Totò Savio as a songwriter and went to the Fonit Cetra label and relied on the producer Mario Lavezzi, starting to interpret songs written by prestigious authors including Bruno Lauzi, Donatella Rettore, Ron, Zucchero Fornaciari, Dario Baldan Bembo, Enrico Ruggeri, Gianni Togni, Umberto Tozzi, Paolo Conte and Gianni Bella.

After the Sanremo experience, Loretta continues her television career, creating many successful programs broadcast by Rai 1 including Il bello della diretta, in spring 1986 on the Thursday prime time, in which she also presents her album, C'è poesia.

In the 1991–92 season she moved to Telemontecarlo where she presented the late night variety Festa di compleanno, broadcast every day from Monday to Friday, where in each episode, the birthday of a famous person was celebrated.

In the same year she released her latest studio album, Si faran ... canzone, recorded for the Fonit Cetra label, which is presented during the show: among the most important tracks on the disc there are Storie all'italiana (song that was also used as the initials of the program) and Temporale.

On Mediaset she led with Mike Bongiorno four editions of the musical program Viva Napoli aired on Rete 4 (from 1998 to 2002), where she dueted with many competitors on very popular Canzone Napoletana repertoire.

On 11 September 1998 she presented Il mio canto libero, a live concert-event dedicated to the death of Italian singer Lucio Battisti (who died just two days before) in Piazza del Campidoglio in Rome, interpreting the songs I giardini di marzo, Io vorrei, non-vorrei ma...se vuoi and other successes of the songwriter.

Returning to the running of the show, she stressed her protests over the alleged minor role that Mike seemed to want to entrust to her[27] On 26 April 2008 Loretta Goggi married her partner Gianni Brezza in Orbetello, in Tuscany.

However, the actress was forced to suspend the tour due to the worsening health conditions of her husband, the director and choreographer Gianni Brezza, who died in Rome on 5 April 2011.

In the same period, the fiction Come fai sbagli begins, directed by Tiziana Aristarco and Riccardo Donna, starring Daniele Pecci, Caterina Guzzanti, Francesca Inaudi and Enrico Ianniello, broadcast on Rai 1 in spring 2016.

Later she was one of the protagonists of another TV fiction Sorelle, directed by Cinzia TH Torrini starring Anna Valle, Ana Caterina Morariu, Giorgio Marchesi and Alessio Vassallo, and successfully broadcast in spring 2017.

On 4 April 2019 the short film Sogni was presented, written and directed by Angelo Longoni, in which Loretta is the protagonist, and where she returns to work in pairs with her sister Daniela.