She is best known for her work as an original cast member of the Nickelodeon sketch comedy series All That and for her role as Lydia Liza Gutman on The WB sitcom The Steve Harvey Show.

She appeared in the 1997 film Good Burger with fellow All That castmates Josh Server, Kenan Thompson, and Kel Mitchell.

She had a minor role in the film Dodgeball: A True Underdog Story in 2004, playing cheerleader Martha Johnstone.

[9] Denberg returned as a recurring guest star in the 2019 revival of All That, reprising her Loud Librarian role and "passing the torch" as the host of Vital Information to new cast member Reece Caddell.

She competed on the twenty-fourth season of Worst Cooks in America, the show's seventh celebrity edition titled That's So '90s, which aired in 2022.