Loriol-sur-Drôme (French pronunciation: [lɔʁjɔl syʁ dʁom], literally Loriol on Drôme; Vivaro-Alpine: L’Auriòu de Droma) is a commune in the Drôme department in southeastern France.

Loriol is situated in the Rhône valley, between Valence and Montélimar.

The neighbouring villages are Livron-sur-Drôme, Mirmande, and Cliousclat.

The medieval fortress was destroyed in the wars of religion, leaving only the ramparts.

During World War II, Loriol was heavily damaged by Allied bombing in August 1944.