It was first located in high schools, churches, office buildings, shopping centers, and other locations scattered throughout the city of San Fernando and the Sylmar neighborhood of Los Angeles, and opened its doors to the public in February 1975 with approximately twelve hundred students.

The large indoor area where the old library was located was turned into an event space with meeting rooms.

In 2009, the college opened the Heath, Athletics, and Fitness building on its new east campus property, relieving the physical education classes that once housed in the storefronts of shopping centers in Sylmar.

By spring 2011, construction began on the new Center for Math and Science building at the college's East Campus.

Also in the fall of 2011, the Los Angeles Community College District purchased an abandoned residential property on Hubbard across from the main campus and built a parking lot and asphalt areas for bungalows.

In addition to its academic degrees, Los Angeles Mission College also provides vocational education and training in which students may receive certificates in Child Development, Family and Consumer Studies, Paralegal, and Computer Applications.

LAMC competes as a member of the California Community College Athletic Association (CCCAA) in the Western State Conference (WSC).