Los Monegros borders seven comarcas: Hoya de Huesca to the North; Somontano de Barbastro, Cinca Medio, and Bajo Cinca to the East; Zaragoza to the West; and Ribera Baja del Ebro and Bajo Aragón-Caspe to the South.

The Sierra de Alcubierre mountain chain crosses the comarca from Northwest to Southeast.

The climate is semiarid, with scarce rainfall and high temperatures in the autumn.

In December 2007, the local government announced that the comarca had been chosen for the site of the Gran Scala, a huge European project to build a "destination city of leisure for all ages."

Designed to include numerous theme parks and casinos, the area would become one of the primary entertainment centers of Europe.