The episode mainly centers on Vincent Chase (Adrian Grenier), whose issues begin to intensify between his ex-girlfriend and his current girlfriend, Sasha Grey.

Although riddled with similar issues, Ari Gold (Jeremy Piven), Eric Murphy (Kevin Connolly), and Turtle (Jerry Ferrara) collaborate with each other in an attempt to orchestrate an intervention for Vince, only to make things worse.

The episode features guest and cameo appearances from notable music artists, including Christina Aguilera and Eminem.

While on the set of production, the couple engage in an intense argument and simultaneously break up, making Vincent leave angrily.

However, upon discovering that his boss Murray has been reporting to Terrence, Eric changes his mind and contacts Scott Lavin.

[2][3][4] In an interview with Entertainment Weekly, Ellin explained that "[Eminem] has a little conflict [...] with Vince [Adrian Grenier].

Upon his approval, Grenier contacted creator Ellin, who agreed to cast Eminem for a future appearance.

[1][2] "Lose Yourself" marks the conclusion of the plot arc between Sasha Grey and Vincent Chase (Adrian Grenier).

[7] Rhys Coiro guest starred as Billy Walsh, having last appeared in the season seven episode "Porn Scenes from an Italian Restaurant".

[9][10][11][12][13] Cameo appearances were made by Mark Cuban, Drew Brees, John Cleese, Jordan Farmar, Ryan Howard, Minka Kelly, The Alchemist, Paul Rosenberg, Royce da 5'9", and Kon Artis.

Philips praised "Lose Yourself", opining that it was an "excellent, extremely entertaining climax to this season's two main plot lines."

He added, "Even though the episode never got around to providing any resolution, the overall journey was engaging enough to make its cliffhanger feel less like a cheap trick to get us to tune in for season eight.

Marnell commended Grenier's acting, as he opined, "I've never hated Vince before this season, but that's the reaction that he was meant to elicit.