"Lose to Win" is the lead single from Fantasia's fourth studio album, Side Effects of You, which was released in April 2013.

[4][5][6] Critics noted that its lyrical content is about the controversy surrounding Fantasia's relationship with Antwaun Cook.

Filming for the video took place in Los Angeles and was directed by Steven Gomillion and Dennis Leupold.

Her man is shown flirting with other women and verbally abusing her, while the screen shows flash backs of happier times in the couple's relationship.

On April 24, 2013 she performed the single on "Good Morning America" on a promotional tour for the album Side Effects of You.