[1] It a tributary of the Troublesome Creek tributary of the North Fork Kentucky River that it joins over the county line in Perry County slightly more than 1 mile (1.6 km) upstream of the mouth of Troublesome, at an altitude of 810 feet (250 m).

[10] Lost Creek has had two post offices in the parts of its watershed that are in Perry County.

[1] It was established on 1923-02-15 by postmaster Andrew Jones, by which point there was a small village at Sixteen Mile Creek, but closed again in November 1936.

[4] Popular folklore is that it was named for Edward P. "Ned" Turner, his son-in-law who married Mary Elizabeth Combs, but at the time Edward was only 12, unmarried (the marriage being in 1891) and still living with his family on Middle Fork.

[4] It is more probable that Combs named it for his neighbour, Edward "Ned" Sizemore.

[4] The post office was taken over by Jeremiah's son John W. Combs who moved it 0.5 miles (0.80 km) upstream to the mouth of minor tributary Perkin's Branch.

[19] (See Rowdy and Stacy for the adjacent Noble Fork of Troublesome Creek.)

[4] The village that grew around it in the 1880s was known as Troublesome, and included general stores (Day's and Sallee's) and a steam-powered saw and grist mill owned by a later postmaster named F. M.