Lostine is a city in Wallowa County, Oregon, United States.

[5] Lostine, Oregon, established a post office in August 1878; W.R. Laughlin was the first postmaster.

[6] Lostine lies along Oregon Route 82 about halfway between Wallowa and Enterprise.

[7] According to the United States Census Bureau, the city has a total area of 0.30 square miles (0.78 km2), all of it land.

The racial makeup of the city was 93.0% White, 2.3% Native American, 3.3% Asian, and 1.4% from two or more races.

32.6% of all households were made up of individuals, and 12.6% had someone living alone who was 65 years of age or older.

23.8% of all households were made up of individuals, and 8.9% had someone living alone who was 65 years of age or older.