Lot-et-Garonne (French pronunciation: [lɔt e ɡaʁɔn] ⓘ, Occitan: Òlt e Garona) is a department in the Nouvelle-Aquitaine region of Southwestern France.

Lot-et-Garonne is one of the original 83 departments created on 4 March 1790, as a result of the French Revolution.

It was created from part of the province of Guyenne and Gascony; originally the territory of the ancient county of Agenais constituted nearly the whole.

[4] Lot-et-Garonne is part of the current region of Nouvelle-Aquitaine and is surrounded by the departments of Lot, Tarn-et-Garonne, Gers, Landes, Gironde, and Dordogne.

In the west of the department, the Landes forest is planted in sand.