Lotbinière-Frontenac is a provincial electoral district in the Chaudière-Appalaches region of Quebec, which elects members to the National Assembly of Quebec.

It consists of the entirety of Lotbinière Regional County Municipality and nearly all of Les Appalaches Regional County Municipality.

It includes the municipalities of Thetford Mines, Saint-Apollinaire, Saint-Agapit, Saint-Gilles, Adstock, Laurier-Station, Sainte-Croix, East Broughton and Saint-Joseph-de-Coleraine.

It was created for the 2012 election from parts of the former Lotbinière and Frontenac electoral districts; Saint-Fortunat was also taken from Richmond electoral district.

CAQ change is from ADQ.