His father, Mohammad Javad Safi Golpaygani, was a high ranking Shia scholar (Marja').

[2][3] While a child in Golpayegan, he was first introduced to basic books in Arabic literature Jalil al-Qadr, and Mullah Abu al-Qasim known as "Qutb".

He would spend the next 15 years there learning and attending lessons under many high ranking Shia scholars, as well as debating Islamic Mysticism.

In one of his essays, he wrote:[12] "Since the time of Al-Ma’mun (d. 833 CE), when the philosophy of the Greeks got introduced to the Muslims, the holy texts of Islam and the fundamentals of religion became targets for the interpretations of philosophers.

They interpreted the relationship between the accident and the eternal as the connection of the effect to the cause, not as the relation of creation with the Creator, and these themes are clearly different.

The most dangerous among these to themselves and to others are those who have produced a blend of the so-called gnosis and the Greek philosophy, thus adding fuel to the fire.

In a speech with Ahmad Mojtahedi Tehrani, he spoke against a poem of Rumi, and Hassan Amoli and said they are "against us".

[13] He is among several high ranking Shia scholars who reject Islamic Mysticism and claims it to be nothing but dreamy and artificial, and that the pursuit of such things is a waste of life.

In an interview with Tasnim News Agency, he highlighted that the Imam Khomeini Relief Committee should focus on reducing poverty and social problems in Iran.

[16] Any society in which the people and their officials show an interest in caring for the weak and the poor has a real life.

It is really unfortunate to see that in the Islamic society, we see unemployed youth and another group who are addicts, and in this situation, the duty of those who are able to help is very heavy, and these individuals and organisations must enter the field of aid with serious effort and know that if they fail, they are really responsible to GodOn 21 October 2021, Mohammad Bagher Ghalibaf met with Safi Golpaygani.

[21] I beseech the independent and freedom-seeking nations of the world to ensure that this inhuman group is not able to continue their horrendous atrocities, and I request all those people whose human conscience is awake, especially the brothers and sisters in faith, to help the oppressed and plundered people of Afghanistan as much as possible, and hastily stand in support of the homeless and shelter-less people, thus fulfilling their human and religious responsibility.When Shahin Najafi released a song called "Naghi", he angered many Shia Muslims in Iran, and around the world.

[22] In the early hours of Tuesday, 1 February 2022, Lotfollah Safi Golpaygani died in a hospital in Qom due to a cardiac arrest at the age of 102.