[9] He was the first Canadian cartoonist to draw three-colour front page illustrations, which allowed him to display his fine-art skills.

[9] He later moved into comic strips, producing Cash and Carrie (similar in format to Tillie the Toiler and Dumb Dora) in 1926, initially for the Merit Newspaper Corporation and later for the Bell Syndicate.

[10] At the end of 1928, he returned to Canada to work for The Mail and Empire,[10] and also opened Lou Skuce Studios, which had its offices at the Old Toronto Star Building at 80 King Street West.

[6][a] They were shown throughout the Canada by newsreel[11] and various publications, and were notable because Skuce drew them all in the living room of his home, relying solely on experience and memory.

Jefferys, and none of the characters he created remained in the public consciousness unlike those by James Simpkins or Doug Wright.

[13] He was instrumental in pushing for the creation of the Lou Marsh Memorial Trophy, which is awarded annually to Canada's top athlete, whether professional or amateur.