[1] He was born to a musician family, as his father, Luis F. Vega Sr., was a jazz saxophonist, and his uncle was singer Héctor Lavoe of the Fania All-Stars.

Vega embarked on his music career as a disc jockey, spinning records at the age of 13.

[2] By 1985, Louie began playing house and block parties in his local Bronx and his first nightclub residency was at the Devil's Nest, in the Bronx, and later he moved to heartthrob (the old Funhouse), Roseland, Studio 54 and the Palladium in Manhattan.

[3] During the 1990s, Vega was playing at one of the most influential nightclubs for house music, The Sound Factory Bar at the Underground Network Parties with promoters Don Welch and Barbara Tucker (also singer).

Louie Vega was ranked #5 at the Top House Artists of 2020 by Traxsource.