This challenge led to his resigning his post in 1782 to dedicate himself to chemistry,[4] collaborating on the Encyclopédie Méthodique and working for industrial applications.

[7] During the Revolution, Guyton de Morveau (then styled Guyton-Morveau) served as Procureur général syndic of the Côte-d'Or département in 1790, was elected a deputy to the Legislative Assembly in 1792, and then to the National Convention.

[9] Guyton de Morveau served on the Committee of Public Safety from 6 April 1793 to 10 July 1793,[10] when he resigned in order to devote his time to the manufacture of firearms, and formation of a corps of balloonists for the French Revolutionary Army.

[12] He became a first-class member of the Académie des sciences in chemistry, on 20 November 1795, and subsequently elected vice-president of the class (1806) and then president (1807).

Besides being a diligent contributor to the scientific periodicals of the day, Guyton wrote Mémoire sur l’éducation publique (1762); a satirical poem entitled Le Rat iconoclaste, ou le Jésuite croqué (1763); Discours publics et éloges (1775–1782); Plaidoyers sur plusieurs questions de droit (1785); and Traité des moyens de désinfecter l’air (1801), describing the disinfecting powers of chlorine, and of hydrochloric acid gas which he had successfully used at Dijon in 1773.