He has also played in the NHL for the Tampa Bay Lightning, Vancouver Canucks, New Jersey Devils, Calgary Flames, and Pittsburgh Penguins.

[1] Domingue was subsequently drafted by the NHL's Phoenix Coyotes and, on June 1, 2011, he was signed by the team to a three-year, entry-level contract.

[3] In the 2014–15 season, after Arizona traded its backup goaltender Devan Dubnyk to the Minnesota Wild, Domingue was called up to the NHL for the first time, to back-up starter Mike Smith.

Domingue made his NHL debut appearing in relief and allowing two goals in a 7–2 defeat to the Ottawa Senators on January 31, 2015.

Following an injury to newly acquired starter Antti Raanta, Domingue was unable to hold the fort, going winless in seven games.

[7][8][9] Before appearing with the Roadrunners, on November 14, 2017, the Coyotes traded Domingue to the Tampa Bay Lightning in exchange for goaltender Michael Leighton and forward Tye McGinn.

[14] On February 10, 2019, Domingue set the franchise record with his tenth straight win, which came in a 5–2 Lightning victory over the Florida Panthers at BB&T Center.

Domingue struggled to assert himself as the Devils backup, collecting just three wins in 16 appearances, before he was placed on waivers and reassigned to the AHL with Binghamton.

[32] The series attracted media attention for Domingue's success versus the Rangers' starting goaltender Igor Shesterkin, the favourite for the Vezina Trophy, who was pulled from the net in both games 3 and 4.

[39] As a free agent from the Penguins, Domingue joined his seventh club in agreeing to a two-year, $1.55 million contract with the New York Rangers on July 13, 2022.

[41] Following injuries to Rangers starter Igor Shesterkin and backup Jonathan Quick, Domingue played in his first NHL game in 18 months, making 25 saves in a 4–1 win against the Minnesota Wild on November 9, 2023.