He was the illegitimate son of Margaretha van Mechelen and Maurice, Prince of Orange, and so a collateral member of the House of Orange-Nassau.
In the same year he was sent to Paris to advise the French king of the forthcoming marriage of the 14-year-old William II of Orange to the 9-year-old English Princess Mary Stuart.
After the death of William II he made his peace with the anti-Orangist regents of the cities of the Dutch Republic and worked with the administration of Johan de Witt, becoming First Noble of Holland.
By 1662 Louis had forged a strong relationship between England and the Dutch Republic and returned to Holland where he died on 28 February 1665.
He and Countess Isabella of Hornes had three surviving sons: He also had seven daughters of whom the three eldest were: Louis of Nassau died in The Hague and was buried there, 6 March 1665, in de Great, or St. James Church.