The Louisa County Courthouse in Wapello, Iowa, United States, was built in 1928.

It was listed on the National Register of Historic Places in 1981 as a part of the County Courthouses in Iowa Thematic Resource.

Columbus Junction desired to be the county seat and they raised $25,000 and built a two-story brick building for a courthouse.

[4] The two-story building was designed in a simplified version of the Art Deco style by the Des Moines architectural firm of Keiffer, Jones and Thomas, and built by Zohbon and Lewis of Des Moines.

The courthouses features a symmetrical facade with end pavilions that slightly project forward.