In the 1880s, Mrs. Martindale held open house for Brighton shop girls on a regular basis, and young Louisa grew up in an environment supportive of her future career.

[2] After the death of William Martindale the family moved to Cornwall, and thence to Germany and Switzerland, finally returning to England to live in Lewes, East Sussex.

She started her own general practice and very soon was asked to join the Lewes Road Dispensary for Women and Children (which in 1911 became the Lady Chichester Hospital, Brighton Branch) as a visiting medical officer.

In 1920, she was instrumental in the setting up of the New Sussex Hospital for Women in Windlesham Road, Brighton, and held the post of senior surgeon and physician there until 1937.

She left Brighton and Hove in 1922, moving to London to start a surgical consultant practice but continued to operate part-time at the New Sussex Hospital.

She also laid the groundwork for research in the treatment of uterine cancer and fibroid growths in women by means of intensive X-ray therapy.

Eventually she became a specialist in the early treatment of cervical cancer by X-ray and she later lectured extensively throughout the UK, the United States, and Germany.

[6] In June 2023, the Royal Sussex County Hospital in Brighton opened a new £500 million, 11-storey building named in honour of Martindale.