Louise is a census-designated place (CDP) in southwestern Wharton County, Texas, United States.

Louise is located on U.S. Route 59 a distance of 9 mi (14 km) west of El Campo in far southwestern Wharton County.

The proportion of workers in industries was as follows: agriculture and forestry 25.7%, construction 5.3%, manufacturing 10.7%, retail 24.2%, transportation 2.8%, finance 0.0%, science and professional 6.3%, education 17.6%, arts and recreation 4.2%, others 0.0%, public administration 3.2%, and armed forces 0.0%.

[21] A Native American campsite was discovered approximately 4 mi (6 km) north of Louise on West Mustang Creek.

The creek was supposedly named because the stagecoach once stopped there on its journey between Texana on the west and Egypt and Richmond on the east.

A nearby location along East Mustang Creek was once known as Santa Anna's Crossing.

[2] In 1881–82, silver mine co-owner John William Mackay constructed the New York, Texas and Mexican Railway between Rosenberg and Victoria.

Italian Count Joseph Telfener recruited many of the builders, which resulted in the nickname the "Macaroni Line".

[2] In June 1893, Sadler and Brown filed a plat of survey of Louise and began selling city lots and farm tracts.

[22] Their sales material called Louise "the greatest country on earth" and touted it as a rice-growing area.

[2] By 1900, the railroad was owned by the Galveston, Harrisburg and San Antonio Railway, which was represented by its local agent D. D.

In 1903, Sadler sold Stockton the Rice Hotel, the Peoples Bank, and the Louise Trading Company.

[24] The same year, Sadler planted 426 acres (172 ha) of rice and made a net profit of $18,000.

Soon afterward, K. H. Payne and William Thomas set up a well-drilling business and began drilling the first deep-water wells for rice irrigation found on the Texas Gulf Coast.

In that year, Louise boasted 25 stores, three garages, two banks, two lumberyards, and two rice warehouses.

Louise featured a large billboard, called the "Outdoor Newspaper", which got national attention.

Attracted by big cities, young people began moving away so that by 1980 the population declined to 310.

[2] Louise is home of the "Brezina Boys", six brothers who all played football for the University of Houston.