[5] Both of her parents were of Spanish descent, and came from prominent political backgrounds, while her connection to the Araneta family is traced to her Basque roots.

[5] In 2006, she temporarily stopped her career as a professor to become a founding member of the MOST (Marcos, Ochoa, Serapio & Tan) Law Firm.

[8][15] When it comes to certain political positions, Araneta Marcos favors the legalization of divorce in the Philippines but for "cogent reasons" maintaining that marriage should not be easily be dissolvable.

[2] Araneta-Marcos temporarily left her own law firm following her husband's victory in the 2022 elections, in order to fulfill her duties as First Lady of the Philippines.

[16] Her assumption of the role, marks the first time that the Philippines has a first lady since Loi Ejercito, the wife of President Joseph Estrada.

In August 2022, she chose to teach criminal law part-time at West Visayas State University in Iloilo, her father's home province.

[22] On August 9, 2022, Araneta Marcos served as the guest of honor at the graduation of the VIP Protection Course Class 128-2022 at the Presidential Security Group (PSG) Headquarters in Malacañang Park.

Ongoing renovation works are being carried out in Bahay ng Pagbabago, the current residence of President Bongbong Marcos.

Renovation works for the other parts of the area are reportedly still ongoing, which is aimed to rejuvenate the city and mansion's significance and rich history.

The program aims to boost Filipino artistry, fashion, and products through various conventions being held in collaboration with the National Commission for Culture and the Arts.

[5] Being a part-time criminal law professor, Araneta Marcos stressed the importance of education within the country, and launches measures to support students in need.

[48] [49] Araneta Marcos also spearheaded the implementation of the Pasig Bigyang Buhay Muli Project, a river rehabilitation project that includes the construction of the Pasig River Esplanade, in collaboration with his husband, President Bongbong Marcos, DHSUD Secretary Jose Acuzar, WTA Design Studio Principal Architect William Ti Jr., and other local officials.

In an interview by broadcaster Anthony Taberna in April 2024, she acknowledged that her relationship with Marcos' vice president, Sara Duterte had declined after she said she saw the latter laughing when her father, former President Rodrigo Duterte publicly called his successor a drug addict ("bangag") and accused their son Sandro of seeking higher political office during a rally against proposed constitutional reform in January 2024.

Liza was working as a lawyer at that time while Bongbong's family was in exile from the Philippines following the People Power Revolution of 1986.

[60] Araneta Marcos is known to be living in a private life prior to her husband's presidential bid, and rarely participates in interviews with the media.