She also appeared in The Alfred Hitchcock Hour, Bonanza, Gunsmoke, Kojak, Hawaii Five-O, Ironside, Columbo, Quincy, M.E., Rhoda, Murder, She Wrote, and The Streets of San Francisco.

On Family Affair, she appeared as Aunt Fran, who leaves Buffy (Anissa Jones) in the care of Uncle Bill (Brian Keith) in the show's first episode.

Latham's character (Betsy Chandler) was the first to learn the real circumstances of Dr. Richard Kimble's wife's death (Helen) in the final episode of The Fugitive (1967).

A newspaper's photo caption in 1965 noted:A stage actress, Louise now leans to making films because "Marnie changed my life, satisfied my soul," she says, "now I want some more of the same.

"[4]She also appeared in such films as Firecreek (1968), Adam at 6 A.M. (1970), White Lightning (1973), The Sugarland Express (1974), Winter Kill (1974), Mass Appeal (1984), The Philadelphia Experiment (1984), Paradise (1991), and Love Field (1992).