She is best known for being a vocalist and guitarist of the alternative rock band Veruca Salt, which she co-founded with Nina Gordon in 1992.

Veruca Salt released a self-funded demo tape and shipped it to labels while playing a handful of small club shows.

Their second album, Eight Arms to Hold You, was released on February 11, 1997, and included the hit "Volcano Girls", which was the opening theme for dark comedy film Jawbreaker.

In 2005, the band toured Australia and released another EP, Lords of Sounds and Lesser Things, followed by a full-length album, IV (2006).

In 2007, the group covered Neil Young's song "Burned" for a breast cancer benefit album and then went dormant.

On April 19, 2014, for Record Store Day, the band released a 10-inch vinyl disc, MMXIV, containing two new songs, "It's Holy" and "The Museum of Broken Relationships".

Veruca Salt's 2000 album, Resolver, the first one released without Gordon, contains lyrics that have been interpreted as "hostile" towards her; however, the two never explained the reasons behind their falling out publicly.

In October 2017, Post was one of 38 women who publicly accused film director James Toback of sexual harassment.