During her pursuit of a master's degree at the University of Nebraska, Pound began to teach at least one course in Anglo-Saxon in the English Department.

In November 1892, Pound, Olivia, and Cather starred in two plays as part of the Union Branch of the University Drama club: one, a farce called The Fatal Pin; the other, Shakespeare Up to Date, a creative endeavor involving a plot of vengeance by Juliet (Pound), Ophelia (Olivia), and Macbeth (Cather).

[1] In January 1895, just before receiving her master's degree, Pound published a short story in the Nebraska State Journal, "By Homeopathic Treatment," describing an attempt at intervention for a socially conscious young woman, Matilda, by her friends, who attempt to introduce Matilda to Clementine, who believes woman's purpose is the selfless amelioration of society's evils.

By then, she had authored "The Romaunt of the Rose: Additional Evidence that it is Chaucer's" (1896)—an essay on Chaucer's role in the English translation of Le roman de la rose—had read her paper "English Pronunciation in Shakespeare's Time" at a gathering of graduate students, and presented her paper "The Relation of the Finnsburg Fragment to the Finn Episode in Beowulf" at the fourth session of the Central Division of the Modern Language Association.

[1][2] Her dissertation, The Comparison of Adjectives in English in the XV and XVI Century, was supervised by Heidelberg's Professor Johannes Hoops.

Louise Pound had an intimate relationship with Ani Königsberger, daughter of the mathematician and historian of science Leo Königsberger,[3][4] in which letters were regularly exchanged for over half a century; Krohn notes that "since the letters that Louise wrote to Ani aren't available, the essence of their friendship remains a mystery",[5] but observes that their correspondence was characteristic of intimate relationships between women of the time, which were "of great emotional strength and complexity... intimacy, love, and erotic passion", even if the exact nature of their friendship, "ardent on Ani's part, almost an infatuation", meant that "that passion was not always fulfilled".

Pound, focusing on her professional life in teaching and scholarship, did not continue her intimate relationship with Königsberger, who later married a physician, Max Phister, who practised at Hong Kong before the Second World War and later at Beidaihe on the coast in North China.

The majority of her research and publications occurred pre-World War II, a time where many linguistic scholars were primarily interested in investigating British and colonial English.

[9] In addition, through investigating the etymology of trade names and word coinage, Pound ascertained that American commercial terminology had become mercurial and boundless.

[10] Pound also delineated multiple instances where American English deviated from standard norms in the pluralization of Latin and Greek loan words.

In writing about Whitman's influences upon his work, Pound identifies specific non-British influences and nuances to Whitman's writing such as Italian opera music; a predilection for French words and expressions involving nouns, slang, social words, and military terms; and unconventional renderings of classic bird poetry which use birds as symbols of fear, loss, and fatality as opposed to the conventional joyful and aesthetic birds metaphorically portrayed.

"[13] The two spent thirty years corresponding about their interests in producing research highlighting differences between American and British English, a concept which was not popular at the time.

[19][20] In 1925, with Kemp Malone and Arthur Garfield Kennedy, she founded the journal American Speech "to present information about English in America in a form appealing to general readers".

Whether or not the friendship occupied an equally noteworthy place in Louise Pound's life is questionable", and observed that "as a woman who enjoyed freedom of movement and independence of thought, Louise would have felt emotionally suffocated by Cather's advances", which was a factor in the ending of their friendship by 1894.

[29] Pound also maintained a distinct rivalry with Mabel Lee, a faculty member of the University of Nebraska physical education department.

Pound was not only the first and only female in school history to earn a men's varsity letter, she was also rated the top player in the country while working on her doctorate at Heidelberg University.

However, at the Ladies' Western Tennis Championship held in Chicago, Illinois, she was defeated playing a three-time U.S. Open singles champion, Juliette Atkinson.

Pound was an all-around athlete showing interest in figure skating, earning a 100-mile cycling medal in 1906, introducing skiing to Lincoln as well as being captain of her school's basketball team.