Her younger sister, Antoinette de Merode, was the future wife of Charles III, Prince of Monaco.

On 28 September 1846 at Brussels, she married Carlo Emanuele dal Pozzo, 5th Prince della Cisterna, an Italian nobleman from one of the few aristocratic families in the Kingdom of Sardinia to bear the title of "prince" as a noble title.

In 1867, her daughter Maria married Prince Amadeo of Savoy, The Duke of Aosta, second son of King Victor Emmanuel II of Italy and his wife Archduchess Adelaide of Austria.

Upon the death of Louise's husband in 1864, their daughter Maria inherited his titles and properties, eventually passing them on to her son.

In 1868, Louise died at the Palazzo dal Pozzo della Cisterna in Turin.