She disliked the strict customs at court; her father complained about her "rebellious nature" in a letter to his friend Count Christian Günther Stolberg.

Initially attentions were drawn to get her married soon with George II of Great Britain's younger son, the Duke of Cumberland but this plan were abandoned following Christian VI's attempt to make her Queen of Sweden during the election of the heir to the vacant Swedish throne in 1742–43 through an engagement with the Prince of Zweibrücken-Birkenfeld who acted as France's candidate or the prince of Mecklenburg who were also considered as a suitable option.

Under her brother Frederick V's reign in 1749, Louise had an affair—and possibly a child—with a valet de chambre from the noble Danish family Ahlefeldt, who was afterwards sentenced to imprisonment for his audacity in Munkholm Fortress in Norway.

Later that year, she was hastily married to Ernest Frederick III, Duke of Saxe-Hildburghausen, with a large dowry to hasten the wedding and calm down the scandal.

As duchess of Saxe-Hildburghausen, she hosted a court known for its formal etiquette, great costs and many parties; she was described as proud and with "royal expenses" in her way of living, amusing herself with ballets, masquerades, balls, hunting and gambling, driving through the streets with a carriage (or, in winters, with a sleigh) of gold and silver.