Claude was the eldest child of Louis XII of France,[2] whom Francis succeeded.

[4] The Treaty of Noyon mandated that if Louise were to die, Charles would be obligated to wed another daughter of King Francis, or Renée, Queen Claude's sister.

In exchange, Charles would pay Francis a pension of a hundred thousand crowns a year until the wedding,[5] and half of that amount annually if the marriage were to remain childless.

[7] The treaty also mandated that Louise was to remain under the care of Queen Claude until she turned eight, and was not to be married until the age of twelve.

[6] However, Louise died at the age of three on 21 September 1518,[8] and Charles was betrothed instead to her younger sister Charlotte, though he would eventually marry Isabella of Portugal once the two countries went to war again.