The route parallels the Texas state line, located along the Sabine River, from a point north of Merryville to the south end of the Toledo Bend Reservoir.

LA 111 was designated in the 1955 Louisiana Highway renumbering, replacing a small portion of former State Route 143, which consisted of several disconnected roadways that paralleled the Sabine River between Starks and Logansport.

LA 111 heads north and crosses a bridge over Bayou Anacoco, simultaneously entering Vernon Parish.

Over the next 13 miles (21 km), LA 111 continues through a sparsely populated pine forest with small clusters of residences visible at points such as Almadane and Evans.

It then reaches a T-intersection with LA 8 (Nolan Trace Parkway) at Burr Ferry, located less than two miles (3.2 km) from the Texas state line at the Sabine River.

In the center of town, LA 111 crosses the Kansas City Southern Railway (KCS) tracks and the four-lane US 171 (Main Street) in quick succession.

The north–south portion was a small part of State Route 143,[9][10][11] a designation which encompassed several disconnected roadways running parallel to the Sabine River between Starks and Logansport.

[5][21] In the late 1990s, a portion of LA 111 heading into Anacoco was relocated, eliminating several zigzags and a right-angle turn next to the KCS Railway grade crossing.