It runs 86.97 miles (139.96 km) in an east–west direction from the junction of U.S. Highway 171 (US 171) and LA 8 in Leesville to US 84 west of Jonesville.

LA 8 turns northeast about five miles (8.0 km) east of Leesville and is called the Slagle Road.

After merging onto MacArthur Drive BR LA 28 exits and follows through downtown Alexandria city streets.

[citation needed] LA 28 exits and merges with US 167 east at the Casson Street exit in Pineville and becomes a part of the Pineville Expressway, which proceeds west along the Fulton Street Bridge, named for Alexander Fulton, the founder of Alexandria.

Much of LA 28 is a four-lane divided highway with a 65 miles per hour (105 km/h) speed limit.

From the west, the route begins on Monroe Street from its intersection with MacArthur Drive.

It then transitions onto the frontage roads alongside the elevated mainline route of US 167/LA 28 (Pineville Expressway).