[citation needed] When the post office was established in 1837, with Sam Petree as its first postmaster, it was discovered Ohio already had a Lewisville, so the spelling was changed to Louisville.

[4][5] Within Louisville's early days, the town competed with the fellow Nimishillen Township community of Harrisburg (also known as Barryville) for growth.

Harrisburg initially flourished due to its accessibility as a stagecoach stop between Canton, Alliance, Cleveland, and Pittsburgh.

Meanwhile, Louisville also grew, due to its location upon the east branch of the Nimishillen Creek, which flows toward Canton.

[6] Today, Harrisburg is now an unincorporated community, marked only by a handful of businesses and a Roman Catholic parish.

By the late 19th Century, Louisville contained many quickly growing businesses, including: a plow manufacturing company, a wooden mill, a brewery, a basket factory, flour mills, tanneries, a brick yard, two hotels, a shoe factory, and a number of taverns/saloons (Louisville had twenty saloons at one point, giving the town a rather notorious reputation).

Furthermore, many of the buildings constructed within Louisville during this time period are listed upon the National Register of Historic Places.

After briefly serving as an all-girls academy and a school for deaf mutes, The building became an orphanage under the guidance of the Vincentian Sisters of Charity.

The old red brick building was razed in 1975, as St. Joseph's moved across the street from St. Thomas Aquinas High School.

Louisville's first public street lights, twelve oil burners, were lit downtown for Christmas 1884.

Her lobbying led the Ohio General Assembly to proclaim September 17 as a statewide "Constitution Day," under a law signed by then-governor Frank J. Lausche.

Her request was approved by both the Senate and the United States House of Representatives, and signed into law by President Dwight D. Eisenhower.

[10] According to the United States Census Bureau, the city has a total area of 5.49 square miles (14.22 km2), all land.

St. Thomas Aquinas High School/Middle School and the Holy Cross Academy at Saint Louis Campus are located within the city of Louisville.